What kind of questions should be asked when choosing between straight MVC4 and a SPA framework like Durandal or Angular?

What kind of questions should be asked when choosing between straight MVC4
and a SPA framework like Durandal or Angular?

I'm in the middle of making this choice right now and I don't know what
kinds of questions I should be asking. One that I believe is valid:
Do I need SEO / natively crawlable pages? If so, stick with MVC4.
One question that I'm not sure about is the impact on performance - I
think this is valid:
Is initial load time very important? If so, stick with MVC4 (like
stackoverflow).
What are some other questions that should be asked that can help point a
developer in the right direction here?
PS - if this question is being asked in a way that doesn't meet quality
standards, I'd appreciate any help modifying it so that it does.